This book constitutes the refereed proceedings of the IFIP WG 8.2, 9.1, 9.4 Joint Working Conference on the Future of Digital Work: The Challenge of Inequality, IFIPJWC 2020, which was supposed to be held in Hyderabad, India, in December 2020, but was held virtually due to the COVID-19 pandemic. This conference was organized for IFIP's 60th anniversary and to commemorate its mission to "e;achieve worldwide professional and socially responsible development and application of ICTs."e;The 22 full papers presented together with an introduction and two keynotes were carefully reviewed and selected from 29 submissions. They are organized in topics on: innovation and entrepreneurship; the social significance of digital platforms; transforming healthcare; and the dark side of digitalization.