About the Editors viii Contributor’s List x Preface to the eighth edition by Adam J Mead xiv Preface to the eighth edition by A Victor Hoffbrand xv Preface to the first edition xvi About the companion website xvii Part I General principles of haematology 1 1 Human stem cells and haemopoiesis 3 Petter S Woll and Adam J Mead 2 Phagocytes 15 Fernando O Martinez, Giuseppe Teti and Siamon Gordon 3 Erythropoiesis in the human 43 Douglas R Higgs, Christian Babbs and Mira Kassouf 4 Lymphocyte development and function 56 Sean Hua Lim 5 The spleen 71 Catherine Hildyard and Daniel Royston 6 Cancer immunotherapy 82 Charlotte O’Brien-Gore, Sophie Papa and Shahram Kordasti 7 Clinical applications of gene editing and therapy 96 Mohsin Badat and James Davies 8 Application of next-generation sequencing in haematology 106 Angela Hamblin and Adele Timbs 9 The molecular basis of haematological malignancies 121 Meng Wang, Niccolo Bolli and George S Vassiliou 10 Laboratory diagnosis of haematological neoplasms 142 Barbara J Bain and Torsten Haferlach Part II Red blood cell disorders and blood transfusion 163 11 Iron metabolism, iron deficiency and disorders of haem synthesis 165 Clara Camaschella and Chaim Hershko 12 Iron overload 188 Clara Camaschella and Maria Domenica Cappellini 13 Megaloblastic anaemia 201 A Victor Hoffbrand 14 Haemoglobin and the inherited disorders of globin synthesis 222 Swee Lay Thein and David Rees 15 Sickle cell disease 249 Neha Bhasin and Elliott P Vichinsky 16 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 269 Paola Bianchi and Narla Mohandas 17 Acquired haemolytic anaemias 292 Rachel Kesse-Adu and Anietie Ekong 18 Red cell immunohaematology 309 Nicole Thornton, Tom Bullock and Shubha Allard Copyrighted Material 19 Clinical blood transfusion 328 Andrew Charlton, Shruthi Narayan and Shubha Allard Part III Lymphoid disorders 361 20 The classification of lymphomas 363 Elias Campo, Gerard Frigola and Stefano A Pileri 21 Adult acute lymphoblastic leukaemia 395 Clare J Rowntree and Adele K Fielding 22 Childhood acute lymphoblastic leukaemia 409 Sujith Samarasinghe, Anthony Moorman and Ajay Vora 23 Chronic lymphocytic leukaemia and other chronic B-cell lymphoproliferative disorders 428 Emili Montserrat 24 T-cell lymphoma and lymphoproliferative disorders 452 Alessandro Broccoli and Pier Luigi Zinzani 25 Hodgkin lymphoma 468 Beth Phillips and Graham P Collins 26 Indolent non-Hodgkin lymphomas 482 Kim Linton and William Townsend 27 Aggressive B-cell non-Hodgkin lymphoma 501 Matthew R Wilson, Jessica Okosun and Kate Cwynarski 28 Multiple myeloma 524 Karthik Ramasamy and Sagar Lonial 29 Amyloidosis 547 Ashutosh D Wechalekar Part IV Stem cell and myeloid disorders 561 30 Inherited aplastic anaemia/bone marrow failure syndromes 563 Inderjeet S Dokal 31 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 583 Austin G Kulasekararaj, Neal S Young and Judith CW Marsh 32 Acute myeloid leukaemia 605 Tumas Beinortas, Paolo Gallipoli and Brian J P Huntly 33 Chronic myeloid leukaemia 630 David T O Yeung and Timothy P Hughes 34 The myelodysplastic syndromes 652 Johanna Ungerstedt, Magnus Tobiasson and Eva Hellström Lindberg 35 Myeloproliferative neoplasms 673 Claire N Harrison, Anna L Godfrey, Mary Frances McMullin and Deepti H Radia 36 Macrophages, dendritic cells and histiocytic disorders 704 Matthew Collin, Venetia Bigley and Chris Bacon 37 Stem cell transplantation 719 Charles Craddock and Ronjon Chakraverty 38 Clonal haematopoiesis 745 Margarete A Fabre and George S Vassiliou Part V Haemostasis and thrombosis 757 39 Normal haemostasis 759 Keith Gomez and John H McVey 40 The vascular function of platelets 782 Stephen P Watson, Neil V Morgan, Paul Harrison and Gillian Lowe 41 Haemophilia and von Willebrand disease 798 Michael A Laffan 42 Rare inherited coagulation disorders 819 Flora Peyvandi and Marzia Menegatti 43 Acquired coagulation disorders 829 Peter W Collins and Jecko Thachil 44 Congenital platelet disorders 848 Maurizio Margaglione and Paul RJ Ames 45 Primary immune thrombocytopenia 861 Nichola Cooper and Drew Provan 46 Thrombotic thrombocytopenic purpura (congenital and acquired) and haemolytic–uraemic syndrome 872 Pier Mannuccio Mannucci, Massimo Cugno and Flora Peyvandi 47 Antithrombotic agents 886 Jeffrey I Weitz 48 Pathogenesis of venous thromboembolism 902 Henry G Watson 49 Prevention and management of venous thromboembolism 921 Nicola Curry and Susan Shapiro 50 Pathogenesis and management of arterial thrombosis 932 Willem L Bor, Dean RPP Chan Pin Yin, Jurriën M ten Berg, Constance Baaten and Hugo ten Cate Part VI Consultative haematology, supportive care and miscellaneous disorders 947 51 Haematological aspects of conditions that occur primarily in tropical countries 949 Imelda Bates and Ivy Ekem 52 Lysosomal storage disorders 966 Derralynn A Hughes 53 Obstetric haematology 974 Gillian Swallow and Sue Pavord 54 Neonatal haematology 989 Irene Roberts and Subarna Chakravorty 55 Supportive care in the management of leukaemia 1005 Renuka Palanicawandar and Jirí Pavlů 56 General consultative haematology 1024 John Willan 57 Consultative haemostasis and thrombosis 1036 Michael A Laffan and Peter MacCallum Index 1055
The latest edition of the key haematology text Haematology, the study and treatment of blood and bone marrow disorders, is a rich and complex discipline that consistently produces cutting-edge medical research. Since 1972, Hoffbrand’s Postgraduate Haematology has acted as the foundational overview and reference text for this subject, introducing generations of trainees and medical residents to the pathogenesis, clinical and laboratory features, and management of blood disorders. The eighth edition of Hoffbrand’s Postgraduate Haematology, now with a new editorial team including leading clinicians and researchers, promises to continue this tradition of excellence with a fully updated text. Lavishly illustrated, comprehensive, and thoughtfully referenced, it is an indispensable resource. Readers of the eighth edition of Hoffbrand’s Postgraduate Haematology will also find: Four-color illustrations and photomicrographs of blood cells and tissues throughout to support key topics New sections analysing recent advances in next generation sequencing, genome editing, clonal haematopoiesis, anticoagulant drugs, diagnostic laboratory tools, and more Companion website with downloadable figures and other tools Hoffbrand’s Postgraduate Haematology is ideal for all postgraduate trainees or residents in haematology, as well as for clinicians and practitioners looking for a reference work on the subject and a guide to the latest research.
Adam J Mead PhD, FRCP, FRCPath, FMedSci Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK Michael A Laffan DM, MRCP, FRCPath Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK Graham P Collins DPhil, FRCP, FRCPath Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK Deborah Hay DPhil, MRCP, FRCPath Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Consulting Editor A Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci Emeritus Professor of Haematology, University College London, London, UK Honorary Consultant Haematologist, Royal Free Hospital, London, UK
