Immunohistology and Molecular Studies of Epithelial Tumors.- Immunohistology and Molecular Studies of Sweat Gland Tumors.- Immunohistology and Molecular Studies of Follicular Tumors.- Use of Immunohistochemical and Molecular Studies in the Evaluation of the Sebaceous Neoplasms.- Cutaneous Metastasis.- Immunohistology and Molecular Studies of Fibrohistiocytic and Myofibroblastic Cutaneous Tumors.- Immunohistology and Molecular Studies of Smooth Muscle and Neural Cutaneous Tumors.- New Insights in Vascular Lesions Development and Identification with Immunohistochemical Markers.- Immunohistology and Molecular Studies of Cutaneous B-cell Lymphomas.- Immunohistology and Molecular Studies of Cutaneous T-cell Lymphomas and Mimics.- Immunohistology of Leukemia Cutis and Histiocytic Tumors.- Immunohistology of Melanocytic Lesions.- Molecular Studies of Melanocytic Lesions.- Sentinel Lymph Node in Melanoma.

Contents

List
of Contributors

Part
I: Immunohistology of Epithelial Tumors

1 Immunohistology and Molecular Studies
of Epithelial Tumors

Heather M. Froehlich and Jose A.
Plaza

Part II: Adnexal
Neoplasms

2 Immunohistology and Molecular Studies
of Sweat Gland Tumors

Ana M. Molina-Ruiz, Laura Fuertes,
and Luis Requena

3 Immunohistology and Molecular Studies
of Follicular Tumors

Olayemi Sokumbi and Jose A. Plaza

4 Use of Immunohistochemical and
Molecular Studies in the Evaluation of the Sebaceous Neoplasms

Doina Ivan, Victor G. Prieto, and
Phyu P. Aung



Part III:

Immunohistology of Cutaneous Metastases and Its Simulators

5 Cutaneous Metastasis

Danielle M. Wehle, Sadia Salim, and
Martin A. Sangueza



Part IV:

Immunohistology of Mesenchymal Neoplasms

6 Immunohistology and Molecular Studies
of Fibrohistiocytic and Myofibroblastic Cutaneous Tumors

Danny Ghazarian, Sebastien Labonte,
Brendan Craig Dickson, and Ayman Al Habeeb

7 Immunohistology and Molecular Studies
of Smooth Muscle and Neural Cutaneous Tumors

Tammie Ferringer

8 New Insights in Vascular Lesions
Development and Identification with Immunohistochemical Markers

Omar P.
Sangüeza
and Julio A. Diaz-Perez



Part V:

Immunohistology of Cutaneous Lymphoma

9 Immunohistology and Molecular Studies
of Cutaneous B-cell Lymphomas

Juan F. García

10 Immunohistology and Molecular Studies of
Cutaneous T-cell Lymphomas and Mimics

Carlos A. Torres-Cabala, Phyu P.
Aung, Roberto N. Miranda, and Jonathan L. Curry

11 Immunohistology of Leukemia Cutis and
Histiocytic Tumors

Maria Teresa Fernández Figueras,
Gustavo Tapia, José Luis Mate, Aurelio Ariza



Part VI:

Immunohistology of Melanocytic Lesions



12 Immunohistology of Melanocytic Lesions
Jonathan L. Curry, Michael T.
Tetzlaff, Priyadharsini Nagarajan, and Carlos A. Torres-Cabala



Part VII:

Molecular Studies of Melanocytic Lesions



13 Molecular Studies of Melanocytic Lesions

Rami Al-Rohil, Priyadharsini
Nagarajan, and Michael T. Tetzlaff



Part VIII:

Immunohistology of Sentinel Lymph Node in Melanoma



14 Sentinel Lymph Node in Melanoma

Victor G. Prieto

State-of-the-art guide to the use of immunohistochemistry studies in the diagnosis of skin tumors Describes the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining Identifies common pitfalls encountered during tumor evaluation Includes supplementary material: sn.pub/extras

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The informative text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains.

With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. Against this background, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

Jose A. Plaza, MD Miraca Life Science, Dermatopathology Division Dallas, Texas, USA   Victor G. Prieto, MD, PhD University of Texas, M. D. Anderson Cancer Center Department of Pathology Houston, Texas, USA